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                          October 11, 2022

       Dr. Todd Harris, Ph.D.
       Chief Executive Officer
       Tyra Biosciences, Inc.
       2656 State Street
       Carlsbad, California 92008

                                                        Re: Tyra Biosciences,
Inc.
                                                            Registration
Statement on Form S-3
                                                            Filed October 3,
2022
                                                            File No. 333-267712

       Dear Dr. Todd Harris:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Daniel
Crawford at 202-551-7767 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Cheston Larson, Esq.