S. Michael Rothenberg
Board Member
Dr. Rothenberg is a trained oncologist who brings two decades of clinical care and drug development experience across multiple therapeutic modalities to the TYRA board spanning target identification through approval. Dr. Rothenberg currently serves as the Chief Medical Officer of insitro, a machine learning-powered drug discovery and development company, where he leads all aspects of clinical development. Prior to insitro, he was vice president of early oncology development and clinical research at Pfizer, where he oversaw Pfizer's oncology and hematology early clinical development portfolio, advancing more than 20 first-in-patient clinical trials, including supervising elranatamab (Elrexfio™, a bispecific antibody) through the first-in-human trial to human proof-of-concept. Prior to Pfizer, he was Vice President of Research and Development at Loxo Oncology, where he led early clinical development for novel, targeted anticancer therapies, including the approved RET inhibitor RETEVMO® (selpercatinib). He previously served as a medical oncologist and researcher focused on targeted therapeutics at Massachusetts General Hospital. Dr. Rothenberg received his B.A. from Yale University and his M.D. and Ph.D. from Stanford University.